I will have to change a few waypoints but that is just because my data isnt up to date.
If I put in my departure and arrival airports simbrief kicks out a take off and landing runway. In this case I get 22R out of JFK and Ill be landing 05 in YYZ. I only care about arrival runway since ATC will give me my departure runway. The ATC in X plane is lacking so I normally cancel my flight plan once airborne.
Here is where I get my fuel and fuel cost index. The 777 is in metric in X plane so I need my fuel in KGs.